O Serviço existe desde 2003 e resultou da fusão da Clínica Universitária de Endocrinologia, Diabetes e Metabolismo com o Núcleo de Diabetes. O seu 1º Diretor foi o Professor Doutor Galvão Teles.
Em 2008 foi reconhecido como o melhor Serviço de Endocrinologia a nível nacional, num estudo feito pela Escola Superior de Saúde Pública.
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